1. Nutrient-deficient strain on the production of lysine.
In many microbes, the acid can be used as raw materials, through the branches of the synthetic pathway of lysine, threonine and methionine. But in the process of metabolism, on the one hand, as a result of acid lysine feedback inhibition of kinase, on the other hand, due to not only be used for synthesis of acid lysine, but also as a synthesis of methionine and Thr of raw materials, therefore, in normal cells, it is hard to accumulate high concentrations of lysine. Industrial use of Corynebacterium glutamicum high-serine as a lysine-deficient strain of the bacteria fermentation. Because it can not be synthesized threonine dehydrogenase, it can not synthesis Serine high, we can not produce methionine and threonine, serine up to the high amount of conditions, can be high in sugar concentration of salts and culture On the base, a large amount of lysine.
2. Traditional production of the classic mutation (lysine) technology and molecular cloning of comparative advantages and disadvantages
High-yielding strains of lysine has been through the classic method to obtain mutation, but they have to increase the mutation of the production line is very difficult.
Molecular cloning and production, production, cost-effective. But it can also cause some problems.
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