“怎么啦”的英文有四种说法，分别为：What's wrong with you ? What's the matter ? What's up ? What happened to you ?
例句：
你怎么啦，我最亲爱的父亲！
What ails you, my dearest father?
“凯茜，怎么啦，亲爱的？”我询问道。
'Cathy, what's the matter, love?' I asked.
“怎么啦，先生，”这位农场主说，“你不知道？
"Why sir, " said the farmer, "didn't you know?
怎么啦——我的美人儿？
What - my Beauty?
为什么？怎么啦？
B: Why ?what happened .
过了一会儿，旅客们又听到机长的声音：“各位，你们猜怎么啦 ？
Shortly thereafter, the passengers heard the captain's voice again, "Guess what, folks.
过了一会儿，旅客们又听到机长的声音：“各位，你们猜怎么啦 ？
Shortly thereafter, the passengers heard the captain's again, "Guess what, folks.
“凯瑟琳，你怎么啦？”主人说。
Catherine, what have you done?' commenced the master.
另外一个小孩则问道：”安东尼怎么啦？
“What’s wrong with Anthony?” asks another.
B：为什么？怎么啦？
B: Why ?what happened.
同事:怎么啦，亲爱的？
Colleague: What's wrong, honey?
安，你看起来很疲惫，怎么啦？
Ann, you look tired, what is the matter?
约翰逊大夫：你怎么啦，李太太？
Dr. Johnson: What’s the matter with you, Mrs. Lee?
怎么啦？你的声音听起来有点沮丧。
What's up? You sound a little down in the dumps?
“您的手怎么啦？”他说。
"What is the matter with your hand?" said he.