in spite of 与regardless of的区别：
1、发音。
in spite of，英 [in spait ɔv] 美 [ɪn spaɪt ʌv]
regardless of，英 [riˈɡɑ:dlis ɔv] 美 [rɪˈɡɑrdlɪs ʌv]
2、含义。
in spite of，不顾;虽然， 尽管…;别看
regardless of，不管， 不顾;无;不拘
3、实际应用用法。
regardless of，prep.不管；不顾；不理会
The club welcomes all new members regardless of age.
俱乐部对所有新成员不分年龄一律欢迎。
He went ahead and did it, regardless of the consequences.
他说干就干了，没有考虑后果。
The amount will be paid to everyone regardless of whether they have children or not.
不管有没有孩子，每个人都会得到相同的金额。
in spite of，不顾;虽然， 尽管…
In spite of great peril, I have survived
虽然处境非常危险，我还是挺过来了。
He was there on the stroke in spite of the rain.
尽管下雨，他还是准时到了。
They are both very cheerful in spite of their colds
他们俩虽然感冒了，可都兴高采烈的。
Their love of life comes in spite of, almost in defiance of,considerable hardship.
尽管面临众多的艰难困苦，他们还是几乎义无反顾地表现出了对生活的热爱。