一、词义不同
full of
翻译：装满、盛满。
例句：The bottle is full of water. 瓶子装满了水。
fill with
翻译：被装满、被盛满。
例句：The bottle is filled with water. 瓶子被装满了水。
二、语境不同
full of 用于主动句。
例句：Whenever I feel upset I would go swimming and then I would be full of energy .
每当我感到难过时，我就会去游泳，然后我就会充满能量。
full with 用于被动句。
例句：Paid in full with one glass of milk.
医药费已由一杯牛奶支付。
三、文法不同
full of 属于宾补，就是宾语补足语，是用来补充说明宾语。
例句：See the book as a mine fullof ORE not GOLD.
将这本书看作是装满矿石的矿山，而不是黄金山。
full with 属于主补，就是主语补足语，用来补充说明主语。
例句：All that we owned and built and grew together, including our children, was
signed over to me in full with no strings attached.
我们的婚后所有东西，包括孩子，都完整地判给我了，没有任何附加条件。
没有be full with，只有be filled with。两者的区别:1、意思不同。befullof意为充满;befi1ledwith意为被什么装满。2、侧重点不同。befu1lof强调“满满的’状态;befi1ledwith更强调动态的过程。3、词组的结构不同。befullof是主动结构;befilledwith是被动结构。
1.be full of:这个词组侧重于表示充满的状态
例1:The room is full of people.
房间里挤满了人。
例2:The bottle is full ofwater.
瓶子里装满了水。
例3:The students here are full ofenergy.
这里的学生们精力充沛。
2. be filled with:这个词组侧重于表示装满的动作和东西
例4:Iwant my life to be filled with happiness.
我想要我的生活充满快乐