issue，problem和question当作名词时，都有“问题”的意思，主要的区别是：
issue——an important question that is in dispute and must be settled . 一般指社会，经济，政治等方面的比较宏观的问题，需要通过争论或者讨论解决。
比如说：Economic Sustainable Development is an important issue of the society.
经济可持续发展是现在社会的一个重要问题。
problem——a state of difficulty that needs to be resolved，a source of difficulty，a question raised for consideration or solution. 主要指客观上存在的难以解决的问题，经常泛指（数学， 物理等）难题或待解决的问题。
比如说：That
depends on how
you tackle the problem.
那取决于你如何处理这个问题。
3. question——an instance of questioning，a sentence of inquiry that asks for a reply，uncertainty about the truth or factuality of existence of something.通常 指用口头或书面提出来要求回答或有待讨论解决的问题或者说是有疑问,有质疑,需要弄 清楚真相的问题。
比如说：You haven't answered my question.
你还没有回答我的问题。